GCxGC
GCxGC (“GC by GC”), also known as Comprehensive Two-Dimensional Gas Chromatography, is a powerful analytic technique that utilizes two columns of differing phase selectivity connected by a modulation device. The set-up of GCxGC improves peak capacity, resolution, and detectability. On average, a GCxGC analysis has five times the sensitivity and gains three times the number of compound identifications of typical GC-MS runs.
As a technique that has been around for over 25 years, some may argue that the technique has been over-hyped and a complicated research tool that doesn’t fit into routine analytical laboratories. However, several routine validated GCxGC methods have demonstrated that the technique is accurate, precise, and robust. Research has shown the benefits of GCxGC in a wide variety of applications (e.g. environmental, metabolomics, petroleum, food safety, fragrance). The benefits include increased peak capacity (i.e. resolution), structured two-dimensional chromatograms (i.e. contour plots), and sensitivity enhancement.
The merits of GCxGC as a separation science are clear, but how will it benefit a routine laboratory? Multiple analyte classes can be combined into a single analysis to save instrument and sample preparation time. Manual review time for non-target screening methods can be reduced with the increased peak resolution of a GCxGC analysis by creating a better library match leading to faster, more confident peak identification. Sample characterization is improved with a GCxGC analysis which increases confidence in decisions based on analytical results. The extra resolution afforded by the GCxGC analysis allows the use of more economical detectors, like the flame ionization detector (FID) or electron capture detector (ECD).
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Instrument Portfolio
GCxGC Time-of-Flight Mass Spectrometer
High Resolution GCxGC-TOFMS
Flame Ionization Detection meets GCxGC
Improve GC peak capacity without sacrificing accuracy
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Benefits of GCxGC for a Routine Laboratory
Explore this resourceApplication Notes
Learn more about our solutions for GCxGC with our library of related application notes.
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203-821-247 | GCxGC-ECD of Organochlorine Pesticides in Cucumber and Tomato |
203-821-243 | Diesel Compound Classification |
203-821-244 | Organochlorine Pesticides |
News or Stories
LECO, in partnership with The Analytical Scientist, is pleased to announce the winners of our Application Challenge! Learn more about novel and interesting applications of GC-MS through interviews with the winners.
Overwhelmed by the volume of data produced by GCxGC-TOFMS? LECO’s ChromaTOF software offers data analysis add-ons that push GCxGC-TOFMS capabilities beyond what was previously feasible.
The global voice of our customer base was reflected back at us during our international Mass Spectrometry team meeting. Let us hear your own thoughts at GCxGC, ASMS, or the Metabolomics Conference later this year!
Videos and Webinars
- 1State of the Art Technology – Aroma, Flavour, and Fragrance From 26 September 1987
- 2GCxGC: THeory, Practice and Optimization From 10 September 2009
- 3Exploring GCxGC Effectiveness as Routine Analysis Technique From 16 February 2010
- 4Forensic Screening of Non-Derivatized Drugs in Urine From 24 June 2010
- 5Small Molecule Metabolite Profiling and Characterization From 16 June 2011
- 6Mega Multi-Analyte Methods and Emerging Pollutants of Concern From 24 September 2012
Posters and Presentations
- Comparative Analysis of Lipophilic Wood Extractives by GCxGC-TOFMS
- Evaluation of a Liquid Cryogen-Free Thermal Modulator for GCxGC
- Volatile Organic Components Human Breath GCxGC-TOFMS Breath analysis is a non-invasive technique for multiple disease biomarkers. High humidity in breath samples provide unique challenges for analysis.
- The Influence of Modulation Period Changes on Slightly Resolved Components Using Variable Modulation in GCxGC
- Evaluation of a New Comprehensive Two-Dimensional Gas Chromatography High-Resolution Time-of-Flight Mass Spectrometry System (GCxGC-HRTTOFMS)